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GENITO URINARY SYSTEM AND SEX HORMONES › GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS › ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS › Antibiotics
carfecillin
G01AA08
Forms & Strengths
- Carfecillin sodium oral tablets (historical/obsolete)
Adult Dosing
- Not currently recommended or widely available for clinical use
- Historically used for urinary tract infections caused by susceptible gram-negative organisms
Pediatric Dosing
- Safety and efficacy in pediatric patients not established
Indications
- Treatment of urinary tract infections due to susceptible Pseudomonas aeruginosa and other gram-negative bacteria
Mechanism of Action
- Carboxypenicillin beta-lactam antibiotic; inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins
Contraindications
- Hypersensitivity to penicillins or other beta-lactam antibiotics
Adverse Reactions
- Hypersensitivity reactions including rash, urticaria, and anaphylaxis
- Gastrointestinal disturbances such as nausea, vomiting, and diarrhea
- Superinfection with resistant organisms upon prolonged use
Drug Interactions
- Probenecid decreases renal tubular secretion of penicillins, increasing serum concentrations
- Potential antagonism with bacteriostatic antibiotics (e.g., tetracyclines, erythromycin)
- May reduce the efficacy of oral contraceptives
Curated Content: Needs Vetting Before Put to Clinical Use