← Search & browse all drugs

nystatin, combinations

G01AA51

Forms & Strengths

Vaginal tablets: Nystatin 100,000 units
Vaginal creams/ointments: Nystatin combined with antibacterial agents (e.g., oxytetracycline, diiodohydroxyquin) or anti-inflammatory agents
Vaginal suppositories containing nystatin combinations

Adult Dosing

Vulvovaginal candidiasis: Insert 1 vaginal tablet (100,000 units) or applicatorful of cream high into the vagina once or twice daily for 14 days
Mixed vaginal infections: Follow specific combination product labeling for duration and frequency (typically 7 to 14 days)

Pediatric Dosing

Not recommended for use in pediatric patients for vaginal indications
Safety and efficacy in post-menarchal adolescents follow adult guidelines if clinically indicated

Indications

Local treatment of vulvovaginal candidiasis (moniliasis)
Treatment of mixed vaginal infections involving Candida albicans and susceptible bacteria or trichomonads depending on the specific combination components

Mechanism of Action

Nystatin binds to sterols (primarily ergosterol) in the cell membrane of sensitive fungi, causing a change in membrane permeability and leakage of intracellular components
Combination components (e.g., antibacterials) provide concurrent activity against bacterial pathogens present in mixed vaginal infections

Contraindications

Hypersensitivity to nystatin or any component of the specific combination product
History of hypersensitivity to other ingredients in the formulation (e.g., specific antibiotics included in combination)

Adverse Reactions

Local irritation, burning, or pruritus upon application
Contact dermatitis
Rare systemic allergic reactions

Drug Interactions

Minimally absorbed systemically via the vaginal route, resulting in a low potential for systemic pharmacokinetic drug interactions
May degrade latex contraceptives (condoms, diaphragms) due to oil or chemical bases in certain cream/ointment formulations

Curated Content: Needs Vetting Before Put to Clinical Use