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GENITO URINARY SYSTEM AND SEX HORMONES › GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS › ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS › Quinoline derivatives
diiodohydroxyquinoline
G01AC01
Adult Dosing
- 1 vaginal tablet inserted daily at bedtime for 10-20 days
- Treatment should be continued during menstruation
Pediatric Dosing
- Safety and efficacy in pediatric patients not established
Indications
- Treatment of vaginitis due to Trichomonas vaginalis, Candida albicans, or mixed infections
Mechanism of Action
- Halogenated quinoline derivative with anti-trichomonal and antifungal activity
- Acts locally in the vagina to eradicate protozoal and fungal pathogens
Contraindications
- Hypersensitivity to iodine or diiodohydroxyquinoline (iodoquinol)
- Iodine intolerance
Adverse Reactions
- Local irritation
- Burning
- Itching
- Allergic contact dermatitis
Drug Interactions
- May interfere with thyroid function tests due to organically bound iodine content
- Topical vaginal preparations may decrease efficacy of local contraceptives
Curated Content: Needs Vetting Before Put to Clinical Use