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GENITO URINARY SYSTEM AND SEX HORMONES › GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS › ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS › Imidazole derivatives
econazole
G01AF05
Forms & Strengths
- Topical nitrate antifungal
- Econazole nitrate cream 1%
Adult Dosing
- Tinea pedis, tinea cruris, tinea corporis: Apply a sufficient amount to cover affected areas once daily for 2 weeks (tinea cruris/corporis) or 4 weeks (tinea pedis)
- Cutaneous candidiasis: Apply once daily for 2 weeks
Pediatric Dosing
- Safety and efficacy in pediatric patients not well established
- Use with caution in pediatric populations for approved indications under clinical supervision
Indications
- Topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by Trichophyton rubrum, T. mentagrophytes, and Epidermophyton floccosum
- Treatment of cutaneous candidiasis
Mechanism of Action
- Azole antifungal that inhibits fungal cytochrome P450-dependent 14-alpha-demethylase
- Depletes ergosterol in the fungal cell membrane, increasing membrane permeability and causing lysis
Contraindications
- Hypersensitivity to econazole or any component of the formulation
- History of hypersensitivity to other imidazole antifungal agents
Adverse Reactions
- Burning
- Pruritus
- Erythema
- Stinging
- Contact dermatitis
Drug Interactions
- Systemic absorption from topical application is low, minimizing significant pharmacokinetic drug interactions
- Potential for minor interactions with potent CYP3A4 inhibitors/inducers if significant systemic absorption occurs
Curated Content: Needs Vetting Before Put to Clinical Use