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GENITO URINARY SYSTEM AND SEX HORMONES › GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS › ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS › Imidazole derivatives
butoconazole
G01AF15
Forms & Strengths
- Vaginal cream 2% (20 mg/applicatorful)
- Vaginal suppository 100 mg
Adult Dosing
- One applicatorful (20 mg) intravaginally once daily for 3 days
- One suppository (100 mg) intravaginally once daily for 3 days
Pediatric Dosing
- Safety and efficacy not established in children under 12 years
- Under 12 years: not recommended
Indications
- Vaginal candidiasis
- Treatment of fungal vaginitis caused by Candida albicans
Mechanism of Action
- Inhibits fungal sterol biosynthesis, altering cell membrane permeability and causing fungal cell death
- Azole class antifungal, which interacts with 14-alpha-demethylase
Contraindications
- Known hypersensitivity to butoconazole or other imidazoles
- First trimester of pregnancy
Adverse Reactions
- Vaginal burning, itching, or irritation
- Abdominal cramping, headache, hives, skin rash
Drug Interactions
- Warfarin: may increase anticoagulant effect
- Phenytoin, cyclosporine, and tacrolimus: butoconazole may increase their levels
Curated Content: Needs Vetting Before Put to Clinical Use