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flutrimazole

G01AF18

Forms & Strengths

Vaginal cream 1%
Topical cream 1%

Adult Dosing

Vulvovaginal candidiasis: 5g of 1% vaginal cream inserted daily for 6 consecutive days
Dermatomycoses: Apply 1% topical cream to affected areas once or twice daily for 2 to 4 weeks

Pediatric Dosing

Safety and efficacy in pediatric patients under 12 years have not been established
Use in adolescents follows adult dosing guidelines if clinically indicated

Indications

Treatment of vulvovaginal candidiasis
Treatment of superficial dermatomycoses (tinea corporis, tinea cruris, tinea pedis)

Mechanism of Action

Broad-spectrum imidazole antifugal agent
Inhibits fungal lanosterol 14-alpha-demethylase, disrupting ergosterol synthesis
Leads to increased fungal cell membrane permeability and cell lysis

Contraindications

Hypersensitivity to flutrimazole or other imidazole antifungals
First trimester of pregnancy (relative contraindication for vaginal formulations)

Adverse Reactions

Local burning sensation
Pruritus at application site
Erythema and local irritation
Contact dermatitis

Drug Interactions

Potential for decreased efficacy of latex contraceptives (condoms, diaphragms) due to excipients in vaginal cream
Minimal systemic absorption limits significant systemic pharmacokinetic drug interactions

Curated Content: Needs Vetting Before Put to Clinical Use