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GENITO URINARY SYSTEM AND SEX HORMONES › GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS › ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS › Imidazole derivatives
tinidazole
G01AF21
Forms & Strengths
- 250mg tablets
- 500mg tablets
Adult Dosing
- 2g single dose for trichomoniasis
- 2g once daily for 2-5 days for giardiasis
- 500mg twice daily for 5-7 days for amoebiasis
Pediatric Dosing
- 15-30mg/kg single dose for trichomoniasis
- 15-30mg/kg once daily for 2-5 days for giardiasis
- 15-30mg/kg twice daily for 5-7 days for amoebiasis
Indications
- trichomoniasis
- giardiasis
- amoebiasis
- infections caused by anaerobic bacteria
Mechanism of Action
- inhibits DNA synthesis
- interferes with DNA helix structure
- inhibits cell division
Contraindications
- hypersensitivity to tinidazole or other nitroimidazoles
- pregnancy during first trimester
- breastfeeding
Adverse Reactions
- nausea and vomiting
- abdominal pain
- metallic taste
- dizziness
- rash
Drug Interactions
- alcohol: may cause disulfiram-like reaction
- warfarin: may increase INR
- phenytoin: may decrease phenytoin levels
- cyclosporine: may increase cyclosporine levels
Curated Content: Needs Vetting Before Put to Clinical Use