← Search & browse all drugs
GENITO URINARY SYSTEM AND SEX HORMONES › OTHER GYNECOLOGICALS › UTEROTONICS › Ergot alkaloids
ergometrine
G02AB03
Forms & Strengths
- Injection: 0.2mg/mL
- Tablet: 0.2mg, 0.5mg
Adult Dosing
- Postpartum hemorrhage: 0.2mg IV/IM, may repeat after 2-4 minutes if necessary
- Severe postpartum hemorrhage: 0.2mg IV, followed by 0.2mg IV every 2-4 minutes as necessary
Pediatric Dosing
- Not recommended for use in pediatric patients
Indications
- Prevention and treatment of postpartum hemorrhage
- Abortion induction, when used in conjunction with other agents
Mechanism of Action
- Stimulates uterine contractions by acting as an agonist at serotonin (5-HT2) receptors
- Increases tone and frequency of uterine contractions, reducing bleeding
Contraindications
- Pregnancy (before delivery of the placenta)
- Hypertension
- Preeclampsia
- Fetal distress
Adverse Reactions
- Nausea
- Vomiting
- Diarrhea
- Hypertension
- Uterine hyperstimulation
- Fetal distress
Drug Interactions
- Concomitant use with other vasoconstrictors may increase risk of hypertension
- May interact with certain anesthetics, such as halogenated anesthetics
Curated Content: Needs Vetting Before Put to Clinical Use