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GENITO URINARY SYSTEM AND SEX HORMONES › OTHER GYNECOLOGICALS › UTEROTONICS › Prostaglandins
dinoprost
G02AD01
Forms & Strengths
- 10mg/mL solution for injection
- 1mg/thin slice vaginal insert
Adult Dosing
- 0.5-1.0mg intracervically or 10-20mg by extra-amniotic injection
- 1mg vaginally every 3-5 hours
Pediatric Dosing
- Safety and efficacy not established
Indications
- induction of labor
- termination of pregnancy
- abortion
- management of severe postpartum hemorrhage
Mechanism of Action
- natural prostaglandin that stimulates uterine contractions
- causes uterine muscles to contract
Contraindications
- pregnancy (beyond intended use for abortion or labor induction)
- history of cesarean section or uterine surgery
- hypersensitivity to dinoprost or prostaglandins
Adverse Reactions
- nausea
- vomiting
- diarrhea
- abdominal pain
- uterine rupture
- hypertension
- fever
Drug Interactions
- oxytocin (augments uterine contractions)
- other prostaglandins (increased risk of adverse reactions)
Curated Content: Needs Vetting Before Put to Clinical Use