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GENITO URINARY SYSTEM AND SEX HORMONES › OTHER GYNECOLOGICALS › OTHER GYNECOLOGICALS › Sympathomimetics, labour repressants
ritodrine
G02CA01
Forms & Strengths
- Tablets: 10mg, 20mg
- Injectable: 10mg/mL, 50mg/5mL
Adult Dosing
- Initial dose: 0.05-0.1 mg/min IV, gradually increased
- Maintenance dose: 0.05-0.35 mg/min IV, adjusted as needed
- Oral: 10-20 mg every 2-4 hours, max 120 mg/day
Pediatric Dosing
- Not recommended for use in pediatric patients
Indications
- Preterm labor inhibition
- Delay of premature birth
- Management of uterine dysrhythmias
Mechanism of Action
- Beta-2 adrenergic agonist
- Relaxes uterine smooth muscle
- Decreases uterine contractions
Contraindications
- Pregnancy at or near term
- Antepartum hemorrhage
- Fetal distress
- Maternal diabetes
- Maternal hypertension
Adverse Reactions
- Nausea and vomiting
- Headache
- Palpitations
- Tachycardia
- Hypotension
- Fever
- Maternal and fetal hyperglycemia
Drug Interactions
- Anesthetics: increased risk of hypotension
- Beta blockers: may inhibit ritodrine's effects
- Corticosteroids: increased risk of maternal and fetal hyperglycemia
- Insulin: may be needed to manage hyperglycemia
- Other sympathomimetics: increased risk of adverse cardiovascular effects
Curated Content: Needs Vetting Before Put to Clinical Use