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buphenine

G02CA02

Forms & Strengths

Oral tablets 3 mg
Oral tablets 6 mg

Adult Dosing

3 mg to 6 mg orally three times daily
Max daily dose typically 18 mg divided

Pediatric Dosing

Safety and efficacy not established in pediatric populations
Not recommended for use in children

Indications

Management of peripheral vascular disorders associated with vasospasm
Adjunctive treatment of circulatory disturbances such as Raynaud's syndrome
Historically used as a uterine relaxant for threatened abortion or premature labor (largely obsolete)

Mechanism of Action

Beta-2 adrenergic receptor agonist causing direct relaxation of vascular and uterine smooth muscle
Produces peripheral vasodilation and increases tissue blood flow

Contraindications

Hypersensitivity to buphenine or related sympathomimetics
Recent myocardial infarction
Severe tachyarrhythmias or unstable angina
Active hemorrhage

Adverse Reactions

Palpitations and tachycardia
Hypotension and dizziness
Flushing and diaphoresis
Nausea and gastrointestinal upset
Anxiety or nervousness

Drug Interactions

Enhanced tachycardic and hypotensive effects with other vasodilators and antihypertensives
Additive sympathomimetic toxicity when co-administered with other beta-agonists
Potential antagonism of effect with non-selective beta-blockers

Curated Content: Needs Vetting Before Put to Clinical Use