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GENITO URINARY SYSTEM AND SEX HORMONES › OTHER GYNECOLOGICALS › OTHER GYNECOLOGICALS › Prolactine inhibitors
bromocriptine
G02CB01
Forms & Strengths
- 2.5mg tablets
- 5mg capsules
- solution for injection 5mg/mL
Adult Dosing
- 2.5mg twice daily initially, titrate to 5-10mg three times daily
- max dose 100mg/day for Parkinson's disease
- 2.5-5mg daily for prolactinomas
- 1.25-5mg once daily for acromegaly
Pediatric Dosing
- safety and efficacy in children not established for most indications
- in cases of prolactin-secreting pituitary adenoma, doses of 2.5-10mg daily have been used
Indications
- treatment of Parkinson's disease
- hyperprolactinemia
- prolactin-secreting pituitary adenoma
- growth hormone-secreting pituitary adenoma (acromegaly)
- Galactorrhea
Mechanism of Action
- acting as a dopamine D2 receptor agonist
- stimulation of postsynaptic dopamine receptors in the brain
- decrease in prolactin secretion from the anterior pituitary
Contraindications
- hypersensitivity to ergot derivatives
- history of severe cardiovascular diseases
- severe psychiatric disorders
- uncontrolled hypertension
Adverse Reactions
- dizziness
- nausea
- vomiting
- constipation
- involuntary movements
- nasal congestion
- erythromelalgia
- hallucinations
Drug Interactions
- synergistic effects with other dopamine agonists
- interactions with antidepressants and MAOIs
- enhance the hypotensive action of antihypertensive drugs
- antagonized by dopamine antagonists
Curated Content: Needs Vetting Before Put to Clinical Use