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GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE › Progestogens and estrogens, fixed combinations
gestodene and ethinylestradiol
G03AA10
Forms & Strengths
- 0.075mg gestodene and 0.02mg ethinylestradiol tablets
- 0.075mg gestodene and 0.03mg ethinylestradiol tablets
Adult Dosing
- 1 tablet once daily for 21 days, followed by 7-day pill-free period
- Begin on Day 1 of menstrual cycle or first Sunday after menstrual period starts
Pediatric Dosing
- Not recommended for use in children under 16 years
- Use in older adolescents should be guided by clinical judgment
Indications
- Contraception
- Treatment of dysmenorrhea
- Treatment of acne
Mechanism of Action
- Gestodene is a progestin with potent progestogenic and anti-estrogenic activity
- Ethinylestradiol is an estrogen with stimulatory effects on endometrium
- Combination suppresses ovulation and thickens cervical mucus
Contraindications
- Active thrombophlebitis or thromboembolic disorders
- Liver tumors or severe liver disease
- Known or suspected breast cancer
- Undiagnosed vaginal bleeding
Adverse Reactions
- Nausea and vomiting
- Headache and migraine
- Breast tenderness and changes
- Breakthrough bleeding
- Mood changes and depression
Drug Interactions
- Inducers of hepatic enzymes (e.g., rifampicin, phenobarbital, carbamazepine)
- Anti-coagulants (increased risk of thrombosis)
- Cyclosporine (increased risk of cyclosporine toxicity)
- Theophylline (increased theophylline levels)
Curated Content: Needs Vetting Before Put to Clinical Use