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GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE › Progestogens and estrogens, fixed combinations
dienogest and ethinylestradiol
G03AA16
Forms & Strengths
- Dienogest 2mg and ethinylestradiol 0.03mg tablets
- Dienogest 2mg and ethinylestradiol 0.02mg tablets
- Monophasic and biphasic oral contraceptive pills
Adult Dosing
- Take one tablet once daily for 21 or 28 days
- Start on the first day of menstrual bleeding for immediate contraceptive protection
- Missed doses should be taken as soon as remembered
Pediatric Dosing
- Not recommended for use in premenarchal girls
- Use in adolescents should be individualized based on patient needs
- Start with the lowest dose and monitor for side effects
Indications
- Contraception for the prevention of pregnancy
- Treatment of moderate acne vulgaris in women
- Treatment of symptoms of androgenetic alopecia in women
Mechanism of Action
- Dienogest is a progestin that inhibits ovulation and thickens cervical mucus
- Ethinylestradiol is an estrogen that inhibits follicular development and ovulation
- Combined effects prevent fertilization and implantation
Contraindications
- Known or suspected pregnancy
- Severe hepatic disease
- History of thrombophlebitis or thromboembolic disorders
- Known or suspected carcinoma of the breast or reproductive organs
Adverse Reactions
- Headache
- Nausea and vomiting
- Breast tenderness
- Weight gain
- Mood changes
- Acne
- Thromboembolic events
Drug Interactions
- Antiepileptic drugs may decrease contraceptive efficacy
- Rifampicin and other antibiotics may decrease contraceptive efficacy
- Atorvastatin and other statins may increase the risk of thromboembolic events
- CYP3A4 inhibitors may increase levels of ethinylestradiol
Curated Content: Needs Vetting Before Put to Clinical Use