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chlormadinone and ethinylestradiol

G03AB07

Forms & Strengths

Oral tablet: chlormadinone acetate 2 mg / ethinylestradiol 0.03 mg

Adult Dosing

1 tablet daily for 21 consecutive days, followed by a 7-day pill-free interval
Begin a new 21/7 cycle on the 8th day after the previous pack

Pediatric Dosing

Indications apply strictly to post-menarchal adolescent females of reproductive age
Not indicated before menarche

Indications

Oral contraception
Treatment of acne vulgaris in women requesting contraception

Mechanism of Action

Combined hormonal contraceptive inhibiting ovulation via suppression of gonadotropins (FSH and LH)
Alters cervical mucus to impede sperm penetration
Modifies endometrium to reduce probability of implantation

Contraindications

Presence or history of venous thromboembolism (VTE) or arterial thromboembolism (ATE)
Known or suspected sex hormone-sensitive malignancies
Liver tumors, severe hepatic disease, or abnormal liver function tests
Undiagnosed vaginal bleeding
Migraine with focal neurological symptoms
Hypersensitivity to active substances or excipients

Adverse Reactions

Headache
Breast pain and tenderness
Irregular uterine bleeding or breakthrough bleeding
Nausea
Weight changes
Mood disturbances, including depressed mood and libido changes

Drug Interactions

Hepatic enzyme inducers (e.g., rifampicin, carbamazepine, phenytoin, St. John's wort) decrease contraceptive efficacy
CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) may increase plasma concentrations
May alter pharmacokinetics of lamotrigine, increasing seizure risk

Curated Content: Needs Vetting Before Put to Clinical Use