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GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › ANDROGENS › 3-oxoandrosten (4) derivatives
fluoxymesterone
G03BA01
Forms & Strengths
- Tablets: 10mg
- Tablets: 5mg
Adult Dosing
- Replacement therapy in hypogonadism: 5-20mg daily
- For male climacteric: 2.5-20mg daily
- For delayed male puberty: 2.5-10mg daily
Pediatric Dosing
- Delayed male puberty: initial dose 2.5mg daily
- Usage not recommended in pediatric patients below 12 years
Indications
- Replacement therapy in conditions associated with a deficiency or absence of endogenous testosterone
- For the treatment of breast neoplasms in postmenopausal women
- Male hypogonadism when the cause is primary (hypogonadal) or secondary (hypothalamic-pituitary) origin
Mechanism of Action
- Derivative of testosterone, acting as an androgen receptor agonist
- Stimulates the development of male sex characteristics and the maintenance of secondary sex characteristics
Contraindications
- Hypersensitivity to fluoxymesterone or any component of the formulation
- Males with known or suspected carcinoma of the breast or prostate
- Pregnant or may become pregnant females
Adverse Reactions
- Edema, gynecomastia, acne, changes in libido
- Priapism, hirsutism, menstrual irregularities, male pattern baldness
Drug Interactions
- Oral anticoagulants, may need dose adjustments
- Corticosteroids, increased edema risk when used in combination
- Insulin and oral hypoglycemic agents, dosages may need adjustment
Curated Content: Needs Vetting Before Put to Clinical Use