← Search & browse all drugs
GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › ESTROGENS › Synthetic estrogens, plain
methallenestril
G03CB03
Adult Dosing
- Menopausal symptoms: 3 to 6 mg orally daily for 3 weeks, followed by a 1-week rest period
- Suppression of lactation: 3 mg twice daily for 5 days
Pediatric Dosing
- Not indicated for pediatric use
Indications
- Menopausal vasomotor symptoms
- Estrogen deficiency states
- Suppression of postpartum lactation
Mechanism of Action
- Non-steroidal synthetic estrogen that binds to estrogen receptors in target tissues, mimicking endogenous 17beta-estradiol
- Suppresses pituitary gonadotropin secretion (FSH and LH)
Contraindications
- Known or suspected carcinoma of the breast
- Estrogen-dependent neoplasia
- Active deep vein thrombosis, pulmonary embolism, or a history of these conditions
- Active or recent arterial thromboembolic disease (stroke, myocardial infarction)
- Liver dysfunction or disease
- Undiagnosed abnormal genital bleeding
- Known or suspected pregnancy
Adverse Reactions
- Nausea, vomiting, abdominal cramps, bloating
- Breast tenderness and enlargement
- Breakthrough bleeding, spotting, changes in menstrual flow
- Headache, migraine, dizziness
- Edema, weight changes
- Thromboembolic events
- Cholestatic jaundice
Drug Interactions
- CYP3A4 inducers (e.g., rifampin, carbamazepine, phenobarbital) may decrease estrogen efficacy
- CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) may increase plasma concentrations of estrogens
- May diminish the efficacy of anticoagulants and antidiabetic agents
- Concomitant use with hepatotoxic drugs may increase the risk of liver toxicity
Curated Content: Needs Vetting Before Put to Clinical Use