← Search & browse all drugs
GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › PROGESTOGENS › Pregnen (4) derivatives
hydroxyprogesterone
G03DA03
Forms & Strengths
- 250mg/mL injection
- 500mg/mL injection
- 100mg, 200mg, 250mg, 500mg capsules
Adult Dosing
- 50-100mg IM weekly for threatened abortion
- 100-200mg IM every 2-4 weeks for endometrial hyperplasia
- 250-500mg IM every week for infertility
Pediatric Dosing
- Safety and efficacy not established in pediatric patients
- 50mg IM every 4 weeks for precocious puberty (off-label)
Indications
- Threatened abortion
- Endometrial hyperplasia
- Infertility
- Habitual abortion
- Amenorrhea
Mechanism of Action
- Progesterone receptor agonist
- Suppresses gonadotropin secretion
- Supports embryonic implantation
- Increases cervical mucus viscosity
Contraindications
- Undiagnosed vaginal bleeding
- Active thrombophlebitis or thromboembolic disorders
- Hypersensitivity to hydroxyprogesterone
- Known or suspected malignancy of breast or reproductive organs
Adverse Reactions
- Injection site reactions
- Allergic reactions
- Weight gain
- Edema
- Dizziness
- Drowsiness
Drug Interactions
- Concomitant use with CNS depressants may increase sedative effects
- Interactions with anticoagulants may increase risk of thrombosis
- Concomitant use with ketoconazole may decrease hydroxyprogesterone efficacy
Curated Content: Needs Vetting Before Put to Clinical Use