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GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › PROGESTOGENS › Pregnen (4) derivatives
progesterone
G03DA04
Forms & Strengths
- Progesterone 100mg capsules
- Progesterone 200mg capsules
- Progesterone 50mg/mL injection
- Progesterone 100mg/mL injection
- Progesterone 8% vaginal gel
- Progesterone 4% vaginal gel
Adult Dosing
- For menstrual disorders: 5-10mg/day for 6-12 days
- For contraception: 30-300mg progesterone implant every 1 year
- For menopausal hormone therapy: 200mg/day progesterone orally for 12 days per 28-day cycle
Pediatric Dosing
- No established pediatric dosing for progesterone for most indications
- Avoid use in pre-pubertal children due to potential for premature closure of epiphyseal growth plates
Indications
- Abnormal uterine bleeding
- Amenorrhea
- Contraception
- Endometriosis
- Hormone replacement therapy
- Luteal phase support during assisted reproductive technologies
Mechanism of Action
- Binds to progesterone receptors to induce transcriptional activity in various reproductive tissues
- Promotes endometrial growth and differentiation
- Inhibits ovulation
- Maintains pregnancy
Contraindications
- Known or suspected pregnancy (if used with estrogen for hormone replacement therapy, or without indication for such use)
- Undiagnosed abnormal vaginal bleeding
- Known or suspected malignancy of the breast or reproductive system
- Active or recent thrombophlebitis or thromboembolic disorders
- Severe liver disease
Adverse Reactions
- Dizziness
- Drowsiness
- Abdominal pain or cramping
- Bloating or breast tenderness
- Changes in menstrual flow
- Fatigue
- Headache
- Mood changes
Drug Interactions
- Increases the effect of bromocriptine
- Increases the metabolism of cyclosporine
- Interferes with the efficacy of certain anticonvulsants (e.g., carbamazepine, phenytoin, phenobarbital)
- May decrease the efficacy of certain vaccines
Curated Content: Needs Vetting Before Put to Clinical Use