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GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › PROGESTOGENS › Estren derivatives
methylestrenolone
G03DC31
Forms & Strengths
- Methylestrenolone is available as oral tablets
- Typical strength is 10mg or 25mg per tablet
- Also available in injectable form
Adult Dosing
- Adult dose for male hypogonadism: 10-25mg orally per day
- For athletic performance enhancement: dosing regimens vary widely
- Typical cycle lasts 6-12 weeks
Pediatric Dosing
- Pediatric use not recommended due to potential for premature closure of epiphyseal plates
- May be considered in cases of hypogonadism under strict supervision
Indications
- Treatment of male hypogonadism
- Off-label for athletic performance enhancement
- Anemia due to bone marrow failure
Mechanism of Action
- Methylestrenolone binds to androgen receptors in target tissues
- Stimulates protein synthesis and muscle growth
- Suppresses gonadotropin secretion
Contraindications
- Prostate cancer or suspicion thereof
- Severe renal or hepatic impairment
- Pregnancy or breastfeeding
- Hypercalcemia
Adverse Reactions
- Hirsutism in women
- Acne
- Testicular atrophy
- Male pattern baldness
- Edema
- Liver enzyme elevations
Drug Interactions
- Warfarin: methylestrenolone may enhance anticoagulant effect
- Insulin and oral hypoglycemics: may decrease glucose tolerance
- Tacrolimus and cyclosporin: potential for increased toxicity
Curated Content: Needs Vetting Before Put to Clinical Use