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hydroxyprogesterone and estrogen

G03FA02

Forms & Strengths

Tablets: 5mg medroxyprogesterone acetate and 1mg estradiol
Injectable: 500mg hydroxyprogesterone caproate and 5mg estradiol cypionate
Patch: 0.25mg estradiol and 2.5mg medroxyprogesterone acetate per day

Adult Dosing

1 tablet daily for 21 days, followed by a 7-day interval
1 injection every 3 months
Apply 1 patch twice a week, for 2 weeks, followed by a 1-week interval

Pediatric Dosing

Not established for pediatric use
Not recommended in prepubertal children
Not indicated in pediatric patients under 18 years of age

Indications

Treatment of moderate to severe vasomotor symptoms due to menopause
Prevention of endometrial hyperplasia in postmenopausal women
Treatment of moderate to severe symptoms of vulvar and vaginal atrophy

Mechanism of Action

Estrogen component reduces the frequency of vasomotor symptoms
Progestin component prevents endometrial hyperplasia
Estrogen and progesterone combination relieves-menopausal symptoms

Contraindications

Undiagnosed vaginal bleeding
Known or suspected cancer of the breast, uterus, or ovary
Active deep vein thrombosis, pulmonary embolism, or history of these conditions

Adverse Reactions

Headache, breast tenderness, and vaginal bleeding
Nausea, dizziness, and back pain
Increased risk of blood clots, stroke, and myocardial infarction

Drug Interactions

Increased risk of thromboembolism with anticoagulants and antiplatelet agents
Reduced efficacy of estrogen and progesterone with rifampin and phenobarbital
Concomitant use with St. John's Wort may reduce hormone levels

Curated Content: Needs Vetting Before Put to Clinical Use