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dydrogesterone and estrogen

G03FA14

Forms & Strengths

Dydrogesterone 10mg and Estradiol 1mg tablets
Dydrogesterone 10mg and Estradiol 2mg tablets
Dydrogesterone 5mg and Estradiol 1mg tablets

Adult Dosing

1 tablet orally once daily
Cyclic regimen: 1 tablet orally once daily for 14 days, followed by a 14-day hormone-free interval
Continuous-combined regimen: 1 tablet orally once daily continuously

Pediatric Dosing

Not recommended for use in pediatric patients under 18 years of age
Use in adolescents for treatment of conditions like primary amenorrhea or dysfunctional uterine bleeding should be individualized

Indications

Hormone replacement therapy (HRT) in postmenopausal women
Treatment of menstrual disorders such as dysmenorrhea, menorrhagia, and metrorrhagia
Treatment of endometriosis

Mechanism of Action

Dydrogesterone is a progestogen that binds to progesterone receptors, causing endometrial transformation and preparing the uterus for implantation of a fertilized ovum
Estradiol is an estrogen that stimulates proliferation of the endometrium and induces the development of female secondary sex characteristics

Contraindications

Known or suspected pregnancy
Undiagnosed vaginal bleeding
Known or suspected cancer of the breast, endometrium, or other estrogen- or progestin-sensitive neoplasms
Active arterial or venous thromboembolism

Adverse Reactions

Nausea, vomiting, breast tenderness, dizziness, headache, weight gain, mood changes, acne, hirsutism, changes in libido

Drug Interactions

May interact with CYP3A4 inhibitors (e.g. ketoconazole, erythromycin, ritonavir) to increase dydrogesterone and estradiol levels
May interact with CYP3A4 inducers (e.g. rifampicin, phenobarbital) to decrease dydrogesterone and estradiol levels
Concomitant use with anticoagulants may increase the risk of thromboembolic events

Curated Content: Needs Vetting Before Put to Clinical Use