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chlormadinone and estrogen

G03FB03

Forms & Strengths

Tablets: chlormadinone 2mg, ethinyl estradiol 0.02mg to 0.05mg
Combination packs with varying estrogen doses

Adult Dosing

Take 1 tablet daily for 21 days, followed by a 7-day tablet-free interval
Start on Day 1 of menstrual cycle or Sunday start with a withdrawal bleed
Missed dose: take as soon as remembered, but only 1 dose per day

Pediatric Dosing

Safety and efficacy not established in girls under 16 years old

Indications

Contraception
Treatment of moderate to severe acne vulgaris
Treatment of primary dysmenorrhea
Treatment of heavy menstrual bleeding

Mechanism of Action

Chlormadinone: progestin that inhibits ovulation and thickens cervical mucus
Estrogen: enhances progestin efficacy, regulates menstrual cycle

Contraindications

Pregnancy, suspected pregnancy, or lactation
Thrombophlebitis, thromboembolic disorders, or history of these conditions
Liver disease, liver tumors, or history of these conditions
Undiagnosed abnormal vaginal bleeding
Known or suspected estrogen-dependent cancer
Hypersensitivity to chlormadinone or estrogen

Adverse Reactions

Nausea
Vomiting
Headache
Dizziness
Breast tenderness
Breakthrough bleeding or spotting
Mood changes, including depression and anxiety

Drug Interactions

Rifampicin: reduces efficacy of chlormadinone and estrogen
Anticonvulsants: reduces efficacy of chlormadinone and estrogen
CYP3A4 inhibitors: increases toxicity risk of chlormadinone and estrogen

Curated Content: Needs Vetting Before Put to Clinical Use