← Search & browse all drugs

follitropin delta

G03GA10

Forms & Strengths

Solution for injection: 12 mcg/0.36 mL in a pre-filled pen
Solution for injection: 36 mcg/1.08 mL in a pre-filled pen
Solution for injection: 72 mcg/2.16 mL in a pre-filled pen

Adult Dosing

Controlled ovarian stimulation: Dosing is individualized based on the patient's anti-Müllerian hormone (AMH) level and body weight
Starting dose: Fixed daily dose of 0.11 to 0.19 mcg/kg based on AMH (up to a maximum initial dose of 12 mcg)
Dose remains fixed throughout the stimulation period (no dose adjustments for follicular response)

Pediatric Dosing

Not indicated for pediatric use

Indications

Controlled ovarian stimulation for the development of multiple follicles in women undergoing assisted reproductive technology (ART) such as in vitro fertilization (IVF)

Mechanism of Action

Recombinant human follicle-stimulating hormone (rFSH) produced by a human cell line (PER.C6)
Binds to FSH receptors on granulosa cells of the ovary
Stimulates follicular growth, proliferation, and estrogen production, promoting multiple follicular development

Contraindications

Hypersensitivity to follitropin delta or any excipients
High baseline levels of FSH indicating primary ovarian failure
Presence of unmanaged thyroid or adrenal dysfunction
Tumors of the hypothalamus, pituitary gland, ovary, breast, or uterus
Ovarian enlargement or cyst not due to polycystic ovary syndrome
Gynaecological bleedings of unknown etiology
Pregnancy or lactation

Adverse Reactions

Ovarian hyperstimulation syndrome (OHSS)
Pelvic pain
Headache
Fatigue
Nausea
Pelvic discomfort
Mood changes

Drug Interactions

No formal drug-drug interaction studies have been performed
Concomitant use with other ovulation-inducing agents (e.g., hCG, clomiphene citrate) may potentiate follicular response and increase OHSS risk

Curated Content: Needs Vetting Before Put to Clinical Use