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GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › OTHER SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › Antigonadotropins and similar agents
gestrinone
G03XA02
Adult Dosing
- 2.5mg twice a week
- dose may be adjusted based on clinical response
Pediatric Dosing
- not recommended for use in pediatric patients
Indications
- treatment of endometriosis
- treatment of pelvic pain
- treatment of heavy menstrual bleeding
Mechanism of Action
- antiestrogenic and antiprogestogenic effects
- inhibits growth of endometrial tissue
- induces atrophy of endometrial implants
Contraindications
- pregnancy or suspected pregnancy
- breastfeeding
- severe liver dysfunction
- undocumented vaginal bleeding
Adverse Reactions
- menstrual irregularities
- nausea and vomiting
- headache
- dizziness
- weight gain
Drug Interactions
- may interact with other hormonal therapies
- may interact with anticoagulant medications
- may interact with certain anti-infective agents
Curated Content: Needs Vetting Before Put to Clinical Use