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GENITO URINARY SYSTEM AND SEX HORMONES › UROLOGICALS › UROLOGICALS › Drugs for urinary frequency and incontinence
meladrazine
G04BD03
Forms & Strengths
- Oral tablets: 50 mg
- Oral tablets: 25 mg
Adult Dosing
- Urinary frequency and urgency: 50 mg orally 3 times daily
- Max daily dose: 150 mg
Pediatric Dosing
- Safety and efficacy not established in pediatric patients
Indications
- Symptomatic treatment of urinary urgency, frequency, and urge incontinence associated with motor urge syndrome
- Overactive bladder
Mechanism of Action
- Anticholinergic agent with direct relaxant effects on the smooth muscle of the urinary bladder
- Competitively blocks muscarinic receptors in the detrusor muscle, reducing bladder contractility
Contraindications
- Hypersensitivity to meladrazine
- Urinary retention
- Gastrointestinal obstruction or severe motility disorders
- Narrow-angle glaucoma
- Myasthenia gravis
Adverse Reactions
- Dry mouth
- Blurred vision
- Constipation
- Drowsiness
- Tachycardia
- Urinary retention
- Dizziness
Drug Interactions
- Additive anticholinergic effects with other antimuscarinic drugs, tricyclic antidepressants, and antihistamines
- Potential antagonism of gastrointestinal prokinetic agents (e.g., metoclopramide)
Curated Content: Needs Vetting Before Put to Clinical Use