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GENITO URINARY SYSTEM AND SEX HORMONES › UROLOGICALS › UROLOGICALS › Drugs for urinary frequency and incontinence
propiverine
G04BD06
Forms & Strengths
- Oral tablet: 5 mg, 15 mg
- Extended-release capsule: 30 mg, 45 mg
Adult Dosing
- Immediate-release: 15 mg orally 1 to 3 times daily
- Extended-release: 30 mg orally once daily, may be increased up to 45 mg daily
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Treatment of urinary incontinence and overactive bladder symptoms (urgency, frequency)
Mechanism of Action
- Anticholinergic agent that competitively inhibits muscarinic receptors
- Exhibits direct calcium-antagonistic and local anesthetic effects on the detrusor muscle of the urinary bladder
Contraindications
- Hypersensitivity to propiverine
- Urinary retention
- Severe gastrointestinal conditions (e.g., toxic megacolon, pyloric stenosis)
- Myasthenia gravis
- Narrow-angle glaucoma
- Severe hepatic impairment
Adverse Reactions
- Dry mouth
- Constipation
- Blurred vision
- Somnolence
- Dizziness
- Urinary retention
- Dyspepsia
Drug Interactions
- Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) may increase plasma concentrations of propiverine
- Concomitant use with other anticholinergics may potentiate therapeutic and adverse effects
- Amantadine, tricyclic antidepressants, and neuroleptics may enhance anticholinergic side effects
Curated Content: Needs Vetting Before Put to Clinical Use