← Search & browse all drugs
GENITO URINARY SYSTEM AND SEX HORMONES › UROLOGICALS › UROLOGICALS › Drugs for urinary frequency and incontinence
tolterodine
G04BD07
Forms & Strengths
- Tablets: 1mg, 2mg
- Capsules: 2mg, 4mg
- Extended-release capsules: 2mg, 4mg
Adult Dosing
- Overactive bladder: 2mg orally twice daily
- Extended-release: 4mg orally once daily
- Maximum dose: 4mg/day
Pediatric Dosing
- Safety and efficacy not established in children
- Not recommended for use in pediatric patients
Indications
- Treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency
- Neurogenic detrusor overactivity
Mechanism of Action
- Competitive muscarinic receptor antagonist
- Decreases bladder contractions
- Increases bladder capacity
Contraindications
- Hypersensitivity to tolterodine or any component of the formulation
- Gastric retention
- Uncontrolled narrow-angle glaucoma
- Urinary retention
Adverse Reactions
- Dry mouth
- Headache
- Constipation
- Dizziness
- Somnolence
- Urinary retention
- Heat stroke in high temperatures
Drug Interactions
- Increase risk of adverse effects with other anticholinergics
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) may increase tolterodine levels
- CYP3A4 inducers (e.g., rifampin) may decrease tolterodine levels
Curated Content: Needs Vetting Before Put to Clinical Use