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GENITO URINARY SYSTEM AND SEX HORMONES › UROLOGICALS › UROLOGICALS › Drugs for urinary frequency and incontinence
imidafenacin
G04BD14
Adult Dosing
- 0.1 mg orally twice daily
- May be increased to 0.2 mg twice daily based on patient response and tolerability
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Treatment of overactive bladder associated with urinary urgency, urinary frequency, and urge incontinence
Mechanism of Action
- Competitive muscarinic receptor antagonist with a relatively high selectivity for the M3 receptor subtype
- Inhibits bladder smooth muscle contractions, reducing detrusor overactivity and improving bladder capacity
Contraindications
- Hypersensitivity to imidafenacin or any component of the formulation
- Urinary retention
- Gastric retention
- Uncontrolled narrow-angle glaucoma
- Severe hepatic impairment
Adverse Reactions
- Dry mouth
- Constipation
- Thirst
- Dyspepsia
- Blurred vision
- Urinary retention
Drug Interactions
- CYP3A4 inhibitors may increase plasma concentrations of imidafenacin
- Concomitant use with other anticholinergic agents may potentiate therapeutic and adverse effects such as dry mouth and constipation
Curated Content: Needs Vetting Before Put to Clinical Use