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GENITO URINARY SYSTEM AND SEX HORMONES › UROLOGICALS › UROLOGICALS › Drugs used in erectile dysfunction
tadalafil
G04BE08
Forms & Strengths
- Tablets: 2.5mg, 5mg, 10mg, 20mg
- Oral tablets for pulmonary arterial hypertension: 20mg
Adult Dosing
- Erectile dysfunction: 10mg as needed, max 20mg per dose
- Benign prostatic hyperplasia: 5mg once daily
- Pulmonary arterial hypertension: 20mg, 40mg once daily
Pediatric Dosing
- Not recommended for pediatric use
- Pulmonary arterial hypertension in children >1 and <18 years: limited data
Indications
- Treatment of erectile dysfunction
- Treatment of benign prostatic hyperplasia
- Treatment of pulmonary arterial hypertension
Mechanism of Action
- Selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5)
- Vasodilation and increased blood flow
- Relaxation of smooth muscle in the corpus cavernosum and pulmonary vasculature
Contraindications
- Concomitant use of nitrates or guanylate cyclase stimulators
- Hypersensitivity to tadalafil or other PDE5 inhibitors
- Priapism or conditions predisposing to priapism
Adverse Reactions
- Headache
- Dyspepsia
- Back pain
- Myalgia
- Nasopharyngitis
- Flushing
Drug Interactions
- Nitrates and nitric oxide donors: can cause hypotension
- Riociguat: can cause hypotension
- Alpha-blockers: can cause hypotension
- Ketoconazole, itraconazole, and other CYP3A4 inhibitors: can increase tadalafil levels
Curated Content: Needs Vetting Before Put to Clinical Use