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GENITO URINARY SYSTEM AND SEX HORMONES › UROLOGICALS › UROLOGICALS › Other urologicals
collagen
G04BX11
Forms & Strengths
- Topical gel 35 mg/mL
- Injectable solution 3.5 mg/mL
- Injectable suspension 25 mg/mL
- Implantable matrix
Adult Dosing
- Apply topically 2-3 times a day
- Inject 1-2 mL per session as needed
- Implant site-specific as directed
Pediatric Dosing
- Not established for children under 18
- Use with caution in pediatric patients
- Dosing should be individualized under medical supervision
Indications
- Treatment of urinary incontinence due to intrinsic sphincter deficiency
- Augmentation of soft tissue
- Tissue bulking for gastroesophageal reflux disease (GERD)
- Correction of vesicoureteral reflux
Mechanism of Action
- Bulks up tissue to improve sphincter function
- Stimulates fibroblast activity to promote collagen deposition
- Increases tissue strength and elasticity
Contraindications
- Hypersensitivity to collagen or bovine products
- Active autoimmune disease
- History of anaphylaxis or severe allergic reactions
Adverse Reactions
- Injection site reactions (pain, redness, swelling)
- Allergic reactions (anaphylaxis, urticaria)
- Immunogenicity (antibody formation)
Drug Interactions
- None well-documented
- Caution with immunosuppressants
- May interact with other injectable substances
Curated Content: Needs Vetting Before Put to Clinical Use