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GENITO URINARY SYSTEM AND SEX HORMONES › UROLOGICALS › DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY › Alpha-adrenoreceptor antagonists
tamsulosin
G04CA02
Forms & Strengths
- Capsules: 0.4 mg
- Modified-release capsules: 0.4 mg
Adult Dosing
- Initial dose: 0.4 mg once daily
- Maximum dose: 0.8 mg once daily
Pediatric Dosing
- Not indicated for use in pediatric patients
Indications
- Treatment of benign prostatic hyperplasia (BPH)
- Relief of symptoms associated with BPH
Mechanism of Action
- Selective alpha-1 adrenergic receptor antagonist
- Relaxes smooth muscle in the prostate and bladder neck
Contraindications
- Hypersensitivity to tamsulosin
- Severe hepatic impairment
Adverse Reactions
- Dizziness
- Headache
- Somnolence
- Flushing
- Retrograde ejaculation
- Hypotension
Drug Interactions
- CYP3A4 inhibitors: increased tamsulosin levels
- Phosphodiesterase-5 inhibitors: increased risk of hypotension
Curated Content: Needs Vetting Before Put to Clinical Use