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GENITO URINARY SYSTEM AND SEX HORMONES › UROLOGICALS › DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY › Testosterone-5-alpha reductase inhibitors
finasteride and tadalafil
G04CB51
Forms & Strengths
- Finasteride 5mg and tadalafil 20mg tablets
- Finasteride 1mg and tadalafil 5mg tablets
- Combination products in varying strengths
Adult Dosing
- Finasteride 5mg and tadalafil 20mg taken orally once daily
- Finasteride 1mg and tadalafil 5mg taken orally once daily
- Dosing adjustments based on individual patient response
Pediatric Dosing
- Not recommended for use in pediatric patients
- Safety and efficacy not established in patients less than 18 years old
Indications
- Treatment of benign prostatic hyperplasia (BPH) with lower urinary tract symptoms
- Treatment of erectile dysfunction (ED)
- Combination therapy for BPH with ED
Mechanism of Action
- Finasteride: 5-alpha reductase inhibitor, reduces dihydrotestosterone (DHT) production
- Tadalafil: phosphodiesterase type 5 (PDE5) inhibitor, increases cyclic guanosine monophosphate (cGMP) levels
- Relaxes smooth muscle, increases blood flow to the penis
Contraindications
- Hypersensitivity to finasteride or tadalafil
- Concomitant use of nitrates, guanylate cyclase stimulators, or riociguat
- Severe hepatic impairment, end-stage renal disease
Adverse Reactions
- Headache, dizziness, nasal congestion, back pain
- Erectile dysfunction, decreased libido, ejaculation disorder
- Hypotension, syncope, priapism
Drug Interactions
- Concomitant use with alpha-blockers, may cause hypotension
- Concomitant use with CYP3A4 inhibitors, may increase tadalafil exposure
- Concomitant use with warfarin, may increase international normalized ratio (INR)
Curated Content: Needs Vetting Before Put to Clinical Use