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SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS › PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES › ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES › Somatropin and somatropin agonists
somatropin
H01AC01
Forms & Strengths
- Injection: 5mg/vial
- Injection: 10mg/vial
- Injection: 15mg/vial
- Prefilled pen: 5mg/1.5mL
- Prefilled pen: 10mg/2mL
- Prefilled pen: 15mg/1.5mL
Adult Dosing
- 0.1-0.3mg/kg/day SC for growth hormone deficiency
- 0.1-0.2mg/kg/day SC for adult growth hormone deficiency
Pediatric Dosing
- 0.16-0.24mg/kg/day SC for growth hormone deficiency
- 0.024-0.043mg/kg/day SC for Turner syndrome
- 0.033-0.067mg/kg/day SC for chronic renal insufficiency
Indications
- Growth hormone deficiency in children
- Growth hormone deficiency in adults
- Short stature associated with Turner syndrome
- Short stature associated with chronic renal insufficiency
Mechanism of Action
- Stimulates growth and cell reproduction
- Regulates metabolism of carbohydrates, fats, and proteins
- Increases serum concentrations of insulin-like growth factor 1 (IGF-1)
Contraindications
- Active cancer or tumor growth
- Allergy to somatropin or its components
- Closed epiphyses in children
- Diabetes mellitus with diabetic retinopathy
Adverse Reactions
- Injection site reactions
- Headache
- Fatigue
- Muscle pain
- Carpal tunnel syndrome
- Increased glucose levels
Drug Interactions
- Glucocorticoids: may require dose adjustments
- Oral estrogens: may reduce effectiveness
- Cyclosporine: may increase risk of nephrotoxicity
- Insulin and oral hypoglycemic agents: may require dose adjustments
Curated Content: Needs Vetting Before Put to Clinical Use