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SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS › PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES › ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES › Somatropin and somatropin agonists
mecasermin
H01AC03
Forms & Strengths
- Injection: 10mg/mL
- Injection: 12.5mg/1.5mL, 20mg/2mL
Pediatric Dosing
- Growth failure in short stature: 0.04-0.12 mg/kg SC twice daily
Indications
- Growth failure in short stature
- Growth hormone deficiency
Mechanism of Action
- Stimulates growth and cell reproduction via growth hormone receptor
- Increases insulin-like growth factor I (IGF-I) levels
Contraindications
- Closed epiphyses, Active or suspected neoplasia
- Known hypersensitivity to mecasermin or any of its excipients
Adverse Reactions
- Hypoglycemia, Lipodystrophy at injection site
- Headache, Injection site reactions
Drug Interactions
- Insulin: may require adjustment of insulin dose
- Oral hypoglycemic agents: use with caution
Curated Content: Needs Vetting Before Put to Clinical Use