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SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS › PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES › ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES › Somatropin and somatropin agonists
mecasermin rinfabate
H01AC05
Forms & Strengths
- vial of 10mg
- prefilled syringe of 10mg/0.5mL
- prefilled syringe of 20mg/0.5mL
Adult Dosing
- not indicated for adult growth hormone deficiency
- dosing based on weight (mg/kg) twice daily by subcutaneous injection
Pediatric Dosing
- initial dose 0.04-0.08 mg/kg twice daily by subcutaneous injection
- titrate dose every 3-6 months
Indications
- treatment of growth failure in children with severe primary insulin-like growth factor-1 deficiency (IGFD)
Mechanism of Action
- recombinant human insulin-like growth factor-1 (rhIGF-1)
- stimulates cell growth and development
Contraindications
- hypersensitivity to mecasermin or any of its excipients
- closed epiphyses
- active or suspected malignancy
- intracranial lesions (especially pituitary tumors)
Adverse Reactions
- hypoglycemia
- lipodystrophy
- tonsillar hypertrophy
- injection-site reactions
Drug Interactions
- insulin: potential to increase risk of hypoglycemia
- oral hypoglycemic agents: potential to increase risk of hypoglycemia
Curated Content: Needs Vetting Before Put to Clinical Use