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SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS › PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES › POSTERIOR PITUITARY LOBE HORMONES › Vasopressin and analogues
desmopressin
H01BA02
Forms & Strengths
- Injectable: 4mcg/mL
- Nasal spray: 10mcg/0.1mL
- Oral tablets: 0.1mg, 0.2mg
- Sublingual tablets: 60mcg, 120mcg, 240mcg
Adult Dosing
- Diabetes insipidus: 0.1-0.4mg PO BID or 5-20mcg intranasally at bedtime
- Nocturnal enuresis: 20-40mcg intranasally at bedtime
Pediatric Dosing
- Diabetes insipidus: 0.05-0.2mg PO BID or 5-10mcg intranasally at bedtime for children > 4 years
- Nocturnal enuresis: 20-30mcg intranasally at bedtime for children > 6 years
Indications
- Central diabetes insipidus
- Nocturnal enuresis
- Hemophilia A and von Willebrand disease
Mechanism of Action
- Mimics antidiuretic hormone (ADH) to increase water reabsorption in collecting ducts
- Stimulates factor VIII and von Willebrand factor release
Contraindications
- Hypersensitivity to desmopressin
- Renal impairment with hyponatremia risk
- SIADH (syndrome of inappropriate antidiuretic hormone secretion)
- Heart failure with fluid overload
Adverse Reactions
- Hyponatremia
- Water intoxication
- Headache
- Nausea
- Flushing
- Nasal irritation with intranasal use
Drug Interactions
- Loop and thiazide diuretics (increased hyponatremia risk)
- SSRIs and tricyclic antidepressants (increased hyponatremia risk)
- Chlorpropamide (potentiates desmopressin effect)
Curated Content: Needs Vetting Before Put to Clinical Use