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SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS › PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES › POSTERIOR PITUITARY LOBE HORMONES › Vasopressin and analogues
ornipressin
H01BA05
Forms & Strengths
- Solution for injection: 1.5 IU/mL, 5 IU/mL, 10 IU/mL
- Ampoules: 1 mL, 5 mL, 10 mL
Adult Dosing
- 0.25-0.5 mL (3.75-7.5 IU) IV or IM, repeated as needed
- 0.1-0.2 mL/min (1.5-3 IU/min) IV infusion, titrated
Pediatric Dosing
- Not recommended for pediatric use due to limited data
- Use with caution in pediatric patients, dose not established
Indications
- Treatment of bleeding esophageal varices
- Diagnosis of diabetes insipidus
- Treatment of postpartum hemorrhage
Mechanism of Action
- Vasopressin receptor agonist, stimulating V1 receptors
- Causing vasoconstriction and increasing blood pressure
- Enhancing intestinal absorption of water and electrolytes
Contraindications
- Hypersensitivity to ornipressin or vasopressin
- Chronic nephritis, coronary artery disease, or asthma
- Vasoconstrictive disease or conditions, e.g. coronary artery disease
Adverse Reactions
- Headache, nausea, abdominal cramps, diarrhea
- Vasopressin-induced water intoxication or hyponatremia
- Chest pain, hypertension, arrhythmias, or myocardial infarction
Drug Interactions
- Demeclocycline, carbamazepine: reduces antidiuretic effect
- Glycoprotein, alpha-adrenergic agonists: enhances vasoconstriction
- Indomethacin: enhances antidiuretic effect of ornipressin
Curated Content: Needs Vetting Before Put to Clinical Use