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SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS › PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES › POSTERIOR PITUITARY LOBE HORMONES › Oxytocin and analogues
oxytocin
H01BB02
Forms & Strengths
- Synthetic oxytocin injection, 10 units/mL
- Synthetic oxytocin injection, 20 units/mL
- Synthetic oxytocin injection, 30 units/mL
- Synthetic oxytocin injection, 40 units/mL
Adult Dosing
- Induction of labor: 1-4 milliunits/min, titrate to 10-20 milliunits/min as needed
- Augmentation of labor: 1-5 milliunits/min, titrate to 10-20 milliunits/min as needed
- Postpartum hemorrhage prophylaxis: 10-30 units IM
- Postpartum hemorrhage treatment: 10-30 units IV
Pediatric Dosing
- Newborn resuscitation: 0.1-0.4 units/kg/dose IV
- Pediatric cardiology: 0.01-0.1 units/kg/dose IV
Indications
- Induction of labor
- Augmentation of labor
- Postpartum hemorrhage prophylaxis
- Postpartum hemorrhage treatment
- Abortion induction
Mechanism of Action
- Stimulates uterine contractions
- Increases contractility of the uterus
- Stimulates lactation
- Stimulates milk ejection reflex
Contraindications
- Known hypersensitivity to oxytocin
- Pregnancy less than 37 weeks
- Fetal distress
- Placental abruption
- Uterine rupture
Adverse Reactions
- Uterine hyperstimulation
- Fetal distress
- Maternal hypotension
- Maternal hypertension
- Nausea and vomiting
- Headache
Drug Interactions
- Potentiates effects of other uterotonic agents
- Enhances effect of anticholinesterases
- Interacts with anesthetics to cause uterine relaxation
Curated Content: Needs Vetting Before Put to Clinical Use