← Search & browse all drugs

carbetocin

H01BB03

Forms & Strengths

Solution for injection: 100 mcg/mL in 1 mL vial

Adult Dosing

Prevention of postpartum hemorrhage: 100 mcg administered as a single IV bolus or IM injection
Administered strictly after delivery of the infant and immediately after elective or urgent caesarean section under epidural or spinal anesthesia

Pediatric Dosing

Not applicable (neonatal and pediatric population)

Indications

Prevention of uterine atony and postpartum hemorrhage following elective or urgent caesarean section under epidural or spinal anesthesia

Mechanism of Action

Long-acting synthetic analogue of oxytocin that binds to oxytocin receptors in the myometrium
Stimulates rhythmic contractions of the uterus, increases frequency of existing contractions, and raises uterine tone
Reduces postpartum blood loss by promoting effective uterine involution

Contraindications

Known hypersensitivity to carbetocin, oxytocin, or any component of the formulation
Use during pregnancy prior to delivery of the infant
Use for the induction of labor
History of cardiovascular disease, severe hepatic or renal disease
Eclampsia and pre-eclampsia

Adverse Reactions

Very common (>10%): Nausea, abdominal pain, vomiting, pruritus, feeling of warmth, hypotension, headache, tremor, tachycardia
Common (1-10%): Metallic taste, chest pain, back pain, dizziness, anemia, chills, fever
Rare (<1%): Dyspnea, anaphylactoid reactions

Drug Interactions

Concomitant administration with oxytocin or other uterotonics may lead to excessive uterine stimulation and hypertonicity; not recommended simultaneously
May enhance the hypertensive effects of ergot alkaloids (e.g., methylergometrine)
Anesthetic agents (e.g., halothane, cyclopropane) may modify the cardiovascular effects of carbetocin, potentially causing hypotension or conduction abnormalities

Curated Content: Needs Vetting Before Put to Clinical Use