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SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS › PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES › HYPOTHALAMIC HORMONES › Anti-gonadotropin-releasing hormones
elagolix
H01CC03
Forms & Strengths
- 150mg tablets
- 200mg tablets
- 100mg tablets
Adult Dosing
- 150mg twice daily for heavy menstrual bleeding
- 200mg twice daily for moderate to severe pain
- 600mg loading dose on first day, followed by 150mg or 200mg twice daily
Pediatric Dosing
- Safety and efficacy not established in pediatric patients
- Not indicated for use in pediatric patients
Indications
- Treatment of moderate to severe pain associated with endometriosis
- Treatment of heavy menstrual bleeding associated with uterine fibroids
Mechanism of Action
- Selective gonadotropin-releasing hormone (GnRH) receptor antagonist
- Decreases production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH)
Contraindications
- Hypersensitivity to elagolix or any components of the formulation
- High-risk pregnancy
- Use with estrogens, progestins, or combination hormonal contraceptives
Adverse Reactions
- Hot flashes
- Night sweats
- Headache
- Fatigue
- Depression and mood changes
Drug Interactions
- May decrease effectiveness of estrogen or progesterone-based contraceptives
- May increase risk of seizures with concomitant use of bupropion or selective serotonin reuptake inhibitors
- May increase risk of thromboembolic events with concomitant use of estrogens
Curated Content: Needs Vetting Before Put to Clinical Use