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SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS › CORTICOSTEROIDS FOR SYSTEMIC USE › CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN › Mineralocorticoids
aldosterone
H02AA01
Forms & Strengths
- Injection: 50 mg/mL
- Tablet: 25 mg, 50 mg, 100 mg
- Oral solution: 25 mg/5 mL
Adult Dosing
- Edema: 50-100 mg/day
- Hypokalemia: 25-50 mg/day
- Congestive heart failure: 25-50 mg/day
Pediatric Dosing
- Edema: 0.5-1.5 mg/kg/day
- Hypokalemia: 0.25-0.5 mg/kg/day
- Not recommended for children under 6 years
Indications
- Edema associated with congestive heart failure
- Nephrotic syndrome
- Cirrhosis of the liver with ascites
- Hypokalemia
Mechanism of Action
- Competitive antagonist of aldosterone receptors
- Inhibits sodium and water reabsorption in the kidneys
- Increases potassium levels by reducing potassium excretion
Contraindications
- Anuria
- Acute renal failure
- Hyperkalemia
- Addison's disease
Adverse Reactions
- Hyperkalemia
- Gynecomastia
- Hirsutism
- Menstrual irregularities
- Nausea
- Dizziness
Drug Interactions
- Potassium supplements: increased risk of hyperkalemia
- ACE inhibitors: increased risk of hyperkalemia
- Digitalis: increased risk of digitalis toxicity
- Lithium: decreased lithium clearance
Curated Content: Needs Vetting Before Put to Clinical Use