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fluocortolone

H02AB03

Forms & Strengths

Cream: 0.2%
Ointment: 0.2%
Suppositories: 0.4 mg, 1 mg
Oral tablets: 5 mg, 20 mg

Adult Dosing

Topical (Cream/Ointment): Apply thin layer 2-3 times daily to affected area
Rectal (Suppositories): Insert 1 suppository 2-3 times daily for acute symptoms
Oral: Initial dose 10-20 mg daily, tapered based on clinical response

Pediatric Dosing

Topical: Apply sparingly once or twice daily in children >1 year if strictly indicated
Oral/Rectal: Safety and efficacy not well established; use lowest effective dose for shortest duration

Indications

Inflammatory and pruritic dermatoses (eczema, dermatitis)
Hemorrhoids and proctitis
Severe inflammatory conditions requiring systemic corticosteroid therapy

Mechanism of Action

Synthetic glucocorticoid that binds to intracellular glucocorticoid receptors
Suppresses transcription of pro-inflammatory cytokines and inflammatory mediators
Reduces vascular permeability, neutrophil accumulation, and immune response

Contraindications

Hypersensitivity to fluocortolone
Untreated bacterial, viral (herpes, varicella), or fungal skin infections
Rosacea and perioral dermatitis (for topical facial use)
Systemic fungal infections (for oral use)

Adverse Reactions

Local topical: skin atrophy, striae, telangiectasia, folliculitis, contact dermatitis
Systemic (prolonged/high-dose): adrenal suppression, Cushingoid symptoms, hyperglycemia, hypertension
Rectal: local burning or irritation

Drug Interactions

CYP3A4 inducers (e.g., rifampin, carbamazepine): may decrease corticosteroid efficacy
CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): may increase systemic exposure and toxicity
Non-steroidal anti-inflammatory drugs (NSAIDs): increased risk of gastrointestinal ulceration
Antidiabetics: corticosteroids may antagonize hypoglycemic effects

Curated Content: Needs Vetting Before Put to Clinical Use