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triamcinolone

H02AB08

Forms & Strengths

Oral: 1mg, 2mg, 4mg, 8mg tablets
Injectable: 10mg/mL, 40mg/mL suspension
Topical: 0.025%, 0.1%, 0.5% cream, ointment
Intra-articular: 10mg/mL, 40mg/mL suspension
Intranasal: 55mcg/spray

Adult Dosing

Allergic rhinitis: 110mcg intranasally once daily
Asthma: 200-400mcg inhalation twice daily
Corticosteroid replacement: 4-12mg orally daily
Intra-articular injection: 2.5-5mg for small joints, 5-15mg for medium joints, 15-30mg for large joints

Pediatric Dosing

Allergic rhinitis (6-12 years): 55mcg intranasally once daily
Asthma (6-12 years): 100-200mcg inhalation twice daily
Corticosteroid replacement: 0.1-0.3mg/kg/day orally in 3 divided doses

Indications

Allergic rhinitis
Asthma
Corticosteroid replacement therapy
Psoriasis
Severe allergies
Rheumatoid arthritis
Intra-articular or soft tissue injection for various inflammatory conditions

Mechanism of Action

Competes with cortisol for glucocorticoid receptors
Inhibits inflammatory cells and mediators
Suppresses immune system response
Inhibits interleukin and tumor necrosis factor production

Contraindications

Hypersensitivity to triamcinolone
Intramuscular injection into an infected site
Live or attenuated vaccines in patients receiving immunosuppressive doses
Systemic fungal infections
Primary infections

Adverse Reactions

Weight gain
Cushing's syndrome
Glucose intolerance
Hypertension
Skin thinning and bruising
Mood changes
Gastrointestinal upset
Increased risk of infections

Drug Interactions

CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) may increase triamcinolone levels
Barbiturates, phenytoin, and rifampicin may decrease triamcinolone levels
Live or attenuated vaccines may be ineffective or increase risk of infection
Warfarin and other anticoagulants may be affected by triamcinolone therapy

Curated Content: Needs Vetting Before Put to Clinical Use