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SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS › CORTICOSTEROIDS FOR SYSTEMIC USE › ANTIADRENAL PREPARATIONS › Anticorticosteroids
trilostane
H02CA01
Forms & Strengths
- 15 mg capsules
- 30 mg capsules
- 60 mg capsules
- 120 mg capsules
Adult Dosing
- Initial dose: 60-120 mg by mouth twice daily
- Maintenance dose: adjusted according to clinical response and cortisol levels
- Maximum dose: 1200 mg daily in divided doses
Pediatric Dosing
- Not established
- Use with caution in children due to limited data
Indications
- Cushing's syndrome
- Cushing's disease
Mechanism of Action
- Inhibits 3-beta-hydroxysteroid dehydrogenase
- Blocks conversion of pregnenolone to progesterone and 17-hydroxypregnenolone to 17-hydroxyprogesterone
- Decreases production of cortisol
Contraindications
- Hypersensitivity to trilostane
- Pregnancy and lactation
Adverse Reactions
- Gastrointestinal upset
- Dizziness
- Headache
- Fatigue
- Hirsutism
Drug Interactions
- Increases effects of warfarin
- Decreases effects of oral contraceptives
- Concomitant use with other steroid synthesis inhibitors may increase risk of adrenal insufficiency
Curated Content: Needs Vetting Before Put to Clinical Use