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SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS › CORTICOSTEROIDS FOR SYSTEMIC USE › ANTIADRENAL PREPARATIONS › Anticorticosteroids
osilodrostat
H02CA02
Forms & Strengths
- Tablets: 1 mg, 2 mg, 5 mg, 10 mg
- Oral administration
Adult Dosing
- Initial dose: 2 mg twice daily
- Titrate every 2 weeks or longer based on cortisol levels
- Maximum dose: 30 mg twice daily
Pediatric Dosing
- Safety and efficacy not established in pediatric patients
- Use in pediatric patients is not recommended
Indications
- Treatment of adult patients with Cushing's disease
- For patients who have failed or are not candidates for surgical treatment
Mechanism of Action
- Inhibits 11β-hydroxylase, an enzyme involved in cortisol synthesis
- Decreases cortisol production in the adrenal glands
Contraindications
- Hypersensitivity to osilodrostat or any component of the formulation
Adverse Reactions
- Adrenal insufficiency
- Hypocortisolism
- Hypotension
- Nausea
- Vomiting
- Increased alanine aminotransferase (ALT) levels
Drug Interactions
- Strong CYP3A4 inducers (e.g., rifampin): decrease osilodrostat exposure
- Strong CYP3A4 inhibitors (e.g., ketoconazole): increase osilodrostat exposure
Curated Content: Needs Vetting Before Put to Clinical Use