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SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS › CORTICOSTEROIDS FOR SYSTEMIC USE › ANTIADRENAL PREPARATIONS › Anticorticosteroids
ketoconazole
H02CA03
Forms & Strengths
- Tablets: 200mg
- Oral suspension: 100mg/5mL
- Topical cream: 2%
- Shampoo: 2%
Adult Dosing
- 200mg orally once daily for fungal infections
- 400mg orally once daily for severe fungal infections
- Apply topical cream or shampoo 1-2 times daily for cutaneous infections
Pediatric Dosing
- Not recommended for children under 2 years
- For children over 2 years, dose is 3.3-6.6mg/kg/day orally in a single daily dose
Indications
- Systemic fungal infections
- Cutaneous fungal infections
- Seborrheic dermatitis
- Dandruff
- Tinea versicolor
Mechanism of Action
- Inhibits cytochrome P450-dependent enzymes
- Interferes with fungal cell membrane synthesis
- Exhibits antifungal activity against a wide range of fungi
Contraindications
- Hypersensitivity to ketoconazole
- Pregnancy and lactation
- Liver disease
- Acute or chronic liver disease
Adverse Reactions
- Nausea and vomiting
- Abdominal pain
- Diarrhea
- Hepatotoxicity
- Allergic reactions
- Endocrine disorders
Drug Interactions
- CYP3A4 substrates (e.g., cyclosporine, tacrolimus)
- Warfarin and other anticoagulants
- Phenytoin and other antiepileptics
- Rifamycin antibiotics
- Asthma medications (e.g., theophylline)
Curated Content: Needs Vetting Before Put to Clinical Use