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SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS › CORTICOSTEROIDS FOR SYSTEMIC USE › ANTIADRENAL PREPARATIONS › Anticorticosteroids
levoketoconazole
H02CA04
Forms & Strengths
- Tablet: 100 mg, 150 mg, 200 mg, 300 mg
- Oral suspension
Adult Dosing
- Initial dose: 100-150 mg twice daily
- Maintenance dose: 100-300 mg daily
- Maximum dose: 600 mg daily
Pediatric Dosing
- Safety and efficacy not established in pediatric patients
- Use with caution in patients with renal impairment
Indications
- Treatment of Cushing's syndrome
- Treatment of endogenous Cushing's syndrome
Mechanism of Action
- Inhibits adrenal steroidogenesis by blocking the enzyme 11-beta hydroxylase
- Decreases cortisol production
Contraindications
- Hypersensitivity to levoketoconazole or other ketoconazole products
- Pregnancy and lactation
- Concomitant use with certain medications (e.g., simvastatin, atorvastatin)
Adverse Reactions
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Hepatotoxicity
- Adrenal insufficiency
Drug Interactions
- Concomitant use with CYP3A4 inhibitors (e.g., ketoconazole, itraconazole) increases levoketoconazole levels
- Concomitant use with CYP3A4 inducers (e.g., rifampin, phenytoin) decreases levoketoconazole levels
- Increases levels of certain medications (e.g., warfarin, midazolam)
Curated Content: Needs Vetting Before Put to Clinical Use