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SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS › THYROID THERAPY › THYROID PREPARATIONS › Thyroid hormones
thyroid gland preparations
H03AA05
Forms & Strengths
- Desiccated thyroid 60mg
- Thyroid extract 65mg
- Levothyroxine (T4) 50-200mcg
- Liothyronine (T3) 5-20mcg
- Thyroid USP (standardized)
Adult Dosing
- 1-3 grains (60-180mg) PO daily
- 30-200mcg levothyroxine PO daily
- 5-20mcg liothyronine PO daily
- Start low, titrate based on TSH levels
Pediatric Dosing
- Newborns: 15-30mcg levothyroxine PO daily
- Infants: 30-50mcg levothyroxine PO daily
- Children: 50-200mcg levothyroxine PO daily
- Adolescents: 100-200mcg levothyroxine PO daily
Indications
- Hypothyroidism
- Thyroid hormone replacement
- Myxedema coma
- Cretinism
- Goiter prevention in areas of iodine deficiency
Mechanism of Action
- Replacement of thyroid hormones T4 and T3
- Stimulation of cellular metabolism
- Enhancement of protein synthesis
- Regulation of growth and development
Contraindications
- Untreated thyrotoxicosis
- Uncontrolled adrenal insufficiency
- Recent myocardial infarction
- Pregnancy-induced hypertension
Adverse Reactions
- Headache
- Nervousness
- Anxiety
- Hair loss
- Weight loss
- Nausea
- Vomiting
- Diarrhea
Drug Interactions
- Warfarin: increased anticoagulant effect
- Digoxin: increased risk of arrhythmias
- Estrogens: increased risk of thyrotoxicosis
- Antidepressants: increased risk of serotonergic adverse effects
Curated Content: Needs Vetting Before Put to Clinical Use