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SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS › THYROID THERAPY › ANTITHYROID PREPARATIONS › Other antithyroid preparations
dibromotyrosine
H03BX02
Adult Dosing
- Initial: 300 mg to 600 mg daily in divided doses
- Maintenance: 100 mg to 300 mg daily adjusted based on clinical response and thyroid function tests
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Management of hyperthyroidism
- Preparation for thyroidectomy in thyrotoxicosis
Mechanism of Action
- Inhibits the coupling of iodotyrosines to form thyroid hormones (T3 and T4)
- Suppresses peripheral deiodination of thyroxine to triiodothyronine
Contraindications
- Hypersensitivity to dibromotyrosine or other iodine/bromine-containing compounds
- Severe hepatic impairment
- Pregnancy and lactation
Adverse Reactions
- Hypothyroidism
- Skin rash, pruritus, and urticaria
- Gastric distress, nausea, and vomiting
- Leukopenia and agranulocytosis (rare)
- Bromism with chronic high-dose use (neurological symptoms)
Drug Interactions
- Antithyroid drugs: May potentiate hypothyroid effects
- Lithium: Concomitant use may increase the risk of hypothyroidism
- Amiodarone: May antagonize or alter thyroid function response
- Bone marrow depressants: Increased risk of leukopenia
Curated Content: Needs Vetting Before Put to Clinical Use